「肝胆膵消化器病学」は横浜市立大学附属病院の消化器内科部門です


  1. Ohkubo H, Masaki T, Matsuhashi N, Kawahara H, Yokoyama T, Nakajima A, Ohkura Y. Histopathologic findings in patients with idiopathic megacolon: a comparison between dilated and non-dilated loops. Neurogastroenterol Motil. 2014 Apr;26(4):571-80. doi: 10.1111/nmo.12303. Epub 2014 Jan 6.
  2. Sumida Y, Nakajima A, Itoh Y. Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/ nonalcoholic steatohepatitis　　World J Gastroenterol 2014 January 14; 20(2): 475-485　
  3. Sakai E, Nakajima A, Kaneda A. Accumulation of aberrant DNA methylation during colorectal cancer development. World J Gastroenterol. 2014 Jan 28;20(4):978-987. Review.
  4. Sakai E, Ohata K, Chiba H, Matsuhashi N, Doi N, Fukushima J, Endo H, Takahashi H, Tsuji S, Yagi K, Matsusaka K, Aburatani H, Nakajima A, Kaneda A. Methylation epigenotypes and genetic features in colorectal laterally spreading tumors. Int J Cancer. 2014 Oct 1;135(7):1586-95. doi: 10.1002/ijc.28814. Epub 2014 Mar 10.
  5. Kohjima M, Enjoji M, Yada R, Yoshimoto T, Nakamura T, Fukuizumi K, Fukushima N, Murata Y, Nakashima M, Kato M, Kotoh K, Shirabe K, Maehara Y, Nakajima A, Nozaki Y, Honda A, Matsuzaki Y, Nakamuta M. Pathophysiological analysis of primary biliary cirrhosis focusing on choline/phospholipid metabolism. Liver Int. 2015 Mar;35(3):1095-102. doi: 10.1111/liv.12526. Epub 2014 Mar 31.
  6. Kitamoto T, Kitamoto A, Yoneda M, Hyogo H, Ochi H, Mizusawa S, Ueno T, Nakao K, Sekine A, Chayama K, Nakajima A, Hotta K. Targeted next-generation sequencing and fine linkage disequilibrium mapping reveals association of PNPLA3 and PARVB with the severity of nonalcoholic fatty liver disease. J Hum Genet. 2014 May;59(5):241-6. doi: 10.1038/jhg.2014.17. Epub 2014 Mar 13.
  7. Olszak T, Neves J, Dowds M, Baker K, Glickman J, Davidson N, Lin CS, Jobin C, Brand S, Sotlar K, Wada K, Katayama K, Nakajima A, Mizuguchi H, Kawasaki K, Nagata K, Kaser A, Zeissig S, Schreiber S, Müller W, Snapper S, Blumberg R,. Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature. 2014 May 22;509(7501):497-502. doi: 10.1038/nature13150. Epub 2014 Apr 6.
  8. Yoneda M, Thomas E, Sumida Y, Imajo K, Hyogo H, Fujii H, Ono M, Kawaguchi T, Eguchi Y, Nakajima A. Uric acid levels decrease with fibrosis progression in patients with nonalcoholic fatty liver disease. Corresponding Author: Dr. Masato Yoneda Clin Biochem. 2014 Aug;47(12):1138-9. doi: 10.1016/j.clinbiochem.2014.04.026. Epub 2014 May 4.
  9. Endo H, Sakai E, Taniguchi L, Kessoku T, Komiya Y, Ezuka A, Kawamura H, Taguri M, Higurashi T, Ohkubo H, Yamada E, Takahashi H, Inamori M, Maeda S, Sakaguchi T, Hata Y, Nagase H, Nakajima A. Risk factors for small-bowel mucosal breaks in chronic low-dose aspirin users: data from a prospective multicenter capsule endoscopy registry. Gastrointest Endosc. 2014 Nov;80(5):826-34. doi: 10.1016/j.gie.2014.03.024. Epub 2014 May 13.
  10. Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K, Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K, Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A, Kodama T, Sakai J. PPARβ/δ activation of CD300a controls intestinal immunity. Sci Rep. 2014 Jun 24;4:5412. doi:10.1038/srep05412. PubMed PMID: 24958459.
  11. Higurashi T, Endo H, Uchiyama T, Uchiyama S, Yamada E, Ohkubo H, Sakai E, Takahashi H, Maeda S, Wada K, Natsumeda Y, Hippo Y, Nakajima A, Nakagama H. Conditional knockout of the leptin receptor in the colonic epithelium revealed the local effects of leptin receptor signaling in the progression of colonic tumors in mice. Carcinogenesis. 2014 Sep;35(9):2134-41. doi: 10.1093/carcin/bgu135. Epub 2014 Jun 23.
  12. Kessoku T, Yoneda M, Sumida Y, Eguchi Y, Fujii H, Hyogo H, Ono M, Kawaguchi T, Nakajima A; Japan Study Group of NAFLD (JSG-NAFLD). Insulin Resistance Correlated With the Severity of Liver Histology in Japanese NAFLD Patients: A Multicenter Retrospective Study. J Clin Gastroenterol. 2014 Jul 10. [Epub ahead of print] No abstract available.
  13. Takahashi H, Ohkubo H, Nakajima A, Shinozaki M, Sato H Comparison of Clinical Guidelines for Ulcerative Colitis: ECCO, BSG, US and Japanese Guidelines with Reference to Surveillance Program JSM Gastroenterol Hepatol 2(3): 1023 (2014)
  14. Chiba H, Takahashi A, Inamori M, Goto T, Ohata K, Matsuhashi N, Nakajima A. Early colon cancer presenting as intussusception and successfully treated using endoscopic submucosal dissection. Endoscopy. 2014;46 Suppl 1:E326-7. doi: 10.1055/s-0034-1377224. Epub 2014 Aug 4.
  15. Takihata M, Nakamura A, Aoki K, Kimura M, Sekino Y, Inamori M, Maeda S, Gotoh E, Nakajima A, Terauchi Y.Comparison of intragastric balloon therapy and intensive lifestyle modification therapy with respect to weight reduction and abdominal fat distribution in super-obese Japanese patients. Obes Res Clin Pract. 2014 Jul-Aug;8(4):e331-8. doi: 10.1016/j.orcp.2013.07.002. Epub 2013 Aug 24.
  16. Kessoku T, Ogawa Y, Yoneda M, Imajo K, Sumida Y, Eguchi Y, Fujii H, Hyogo H, Ono M, Suzuki Y, Kawaguchi T, Chayama K, Tanaka S, Fujimoto K, Anzai K, Saibara T, Sata M, Itoh Y, Nakajima A, Jsg-Nafld TO.Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease. World J Gastroenterol. 2014 Aug 7;20(29):10108-14. doi: 10.3748/wjg.v20.i29.10108.
  17. Ichikawa Y, Nagashima Y, Morioka K, Akimoto K, Kojima Y, Ishikawa T, Goto A, Kobayashi N, Watanabe K, Ota M, Fujii S, Kawamata M, Takagawa R, Kunizaki C, Takahashi H, Nakajima A, Maeda S, Shimada H, Inayama Y, Ohno S, Endo I. Colorectal laterally spreading tumors show characteristic expression of cell polarity factors, including atypical protein kinase C λ/ι, E-cadherin, β-catenin and basement membrane component. Oncol Lett. 2014 Sep;8(3):977-984. Epub 2014 Jun 20.
  18. Fujisawa T, Kagawa K, Watanabe S, Hisatomi K, Kubota K, Sato H, Nakajima A, Matsuhashi N. Endoscopic nasobiliary drainage for obstructive jaundice using either a 5 Fr or 7 Fr catheter: a prospective, randomized trial. BMC Gastroenterol. 2014 Sep 18;14(1):161. [Epub ahead of print] PubMed PMID: 25234181.
  19. Yoneda M, Imajo K, Saito S, Nakajima A. Screening of nonalcoholic fatty liver disease in patients with coronary heart disease by transient elastography: proceed with caution Wiener klinische Wochenschrift Accepted 28 September 2014
  20. Yamada E, Inamori M, Uchida E, Tanida E, Izumi M, Takeshita K, Fujii T, Komatsu K, Hamanaka J, Maeda S, Kanesaki A, Matsuhashi N, Nakajima A. Association Between the Location of Diverticular Disease and the Irritable Bowel Syndrome: A Multicenter Study in Japan. Am J Gastroenterol. 2014 Dec;109(12):1900-5. doi: 10.1038/ajg.2014.323. Epub 2014 Oct 21.
  21. Taniguchi L, Higurashi T, Uchiyama T, Kondo Y, Uchida E, Uchiyama S, Jono F, Hamanaka J, Kuriyama H, Hata Y, Endo H, Takahashi H, Nagase H, Matsuhashi N, Nakajima A.　 Metabolic factors accelerate colorectal adenoma recurrence. BMC Gastroenterol. 2014 Oct 23;14:187. doi: 10.1186/1471-230X-14-187.
  22. Ida T, Inamori M, Hamanaka J, Chiba H, Kusakabe A, Morohashi T, Nakajima A, Maeda S, Goto T. Endoscopic removal of a migrated stent in the gallbladder. Endoscopy. 2014;46 Suppl 1:E539-40. doi: 10.1055/s-0034-1377634. Epub 2014 Nov 19. No abstract available.
  23. Sakai E, Endo H, Taguri M, Kawamura H, Taniguchi L, Hata Y, Ezuka A, Nagase H,Kessoku T, Ishii K, Arimoto J, Yamada E, Ohkubo H, Higurashi T, Koide T, Nonaka T, Takahashi H, Nakajima A. Frequency and risk factors for rebleeding events in patients with small bowel angioectasia. BMC Gastroenterol. 2014 Nov 28;14(1):200.[Epub ahead of print] PubMed PMID: 25430814.
  24. Yamada E, Inamori M, Watanabe S, Sato T, Tagri M, Uchida E, Tanida E, Izumi M,Takeshita K, Fujisawa N, Komatsu K, Hamanaka J, Kanesaki A, Matsuhashi N,Nakajima A. Constipation is not associated with colonic diverticula: amulticenter study in Japan. 2014 Dec 3. doi:10.1111/nmo.12478. [Epub ahead of print] PubMed PMID: 25469640.
  25. Muto M, Matsufuji H, Tomomasa T, Nakajima A, Kawahara H, Ida S, Ushijima K,Kubota A, Mushiake S, Taguchi T. Pediatric chronic intestinal pseudo-obstruction is a rare, serious, and intractable disease: A report of a nationwide survey in Japan. J Pediatr Surg. 2014 Dec;49(12):1799-803. doi: 10.1016/j.jpedsurg.2014.09.025. Epub 2014 Nov 6. PubMed PMID: 25487487.
  26. Kusakabe A, Nonaka T, Sekino Y, Iida H, Endo H, Koide T, Takahashi H, Fujita K, Yoneda M, Goto A, Gotoh E, Maeda S, Nakajima A, Nosaka C, Inamori M. Effects of ramosetron oral disintegrating tablets on gastric emptying: crossover study using the 13C-acetic acid breath test. Hepatogastroenterology. 2014 Jul-Aug;61(133):1279-82.
  27. Kobayashi N, Sato T, Kato S, Watanabe S, Hosono K, Kubota K, Takedaz K, Endo I, Nakajima A, Maeda S, Ichikawa Y. Endoscopic treatment of postoperative benign bile duct stricture compared with malignant bile duct stricture. Hepatogastroenterology. 2014 Sep;61(134):1507-18.
  28. Inamori M, Togawa J, Matsumoto S, Harad K, Matsuura M, Iida H, Akimoto K, Endo H, Nonaka T, Takahashi H, Koide T, Shibata W, Ida T, Kusakabe A, Nagase H, Tominaga S, Tanaka K, Gotoh E, Nakajima A, Maeda S. Protective effect of lactoferrin on acute acid reflux-induced esophageal mucosal damage. Hepatogastroenterology. 2014 Sep;61(134):1595-600.
  29. Endo H, Sakai E, Kato T, Umezawa S, Higurashi T, Ohkubo H, Nakajima A. Small bowel injury in low-dose aspirin users. J Gastroenterol. 2014 Dec 14. [Epub ahead of print]
  30. Imajo K, Hyogo H, Yoneda M, Honda Y, Kessoku T, Tomeno W, Ogawa Y, Taguri M, Mawatari H, Nozaki Y, Fujita K, Kirikoshi H, Saito S, Sumida Y, Ono M, Wada K, Nakajima A, Eguchi Y. LDL-Migration Index (LDL-MI), an Indicator of Small Dense Low-Density Lipoprotein (sdLDL), Is Higher in Non-Alcoholic Steatohepatitis than in Non-Alcoholic Fatty Liver: A Multicenter Cross-Sectional Study. PLoS One. 2014 Dec 26;9(12):e115403. doi: 10.1371/journal.pone.0115403. eCollection 2014.
  31. Matsuura M, Inamori M, Endo H, Matsuura T, Kanoshima K, Inoh Y, Fujita Y, Umezawa S, Fuyuki A, Uchiyama S, Higurashi T, Ohkubo H, Sakai E, Iida H, Nonaka T, Futagami S, Kusakabe A, Maeda S, Nakajima A. Lubiprostone decreases the small bowel transit time by capsule endoscopy: an exploratory, randomised, double-blind, placebo-controlled 3-way crossover study. Gastroenterol Res Pract. 2014;2014:879595. doi: 10.1155/2014/879595. Epub 2014 Dec 29.

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