「肝胆膵消化器病学」は横浜市立大学附属病院の消化器内科部門です


  1. Kagawa K, Kubota K, Kurita Y, Takagi Y, Ishii K, Hasegawa S, Iwasaki A, Sato T, Fujita Y, Kato S, Watanabe S, Sekino Y, Hosono K, Nakajima A. Effect of preventive closure of the frenulum after endoscopic papillectomy: a prospective pilot study. J Gastroenterol Hepatol. 2019 Nov 6. doi: 10.1111/jgh.14922. [Epub ahead of print] PubMed PMID: 31693767.
  2. Oeda S, Takahashi H, Imajo K, Seko Y, Ogawa Y, Moriguchi M, Yoneda M, Anzai K, Aishima S, Kage M, Itoh Y, Nakajima A, Eguchi Y. Accuracy of liver stiffness measurement and controlled attenuation parameter using FibroScan(®) M/XL probes to diagnose liver fibrosis and steatosis in patients with nonalcoholic fatty liver disease: a multicenter prospective study. J Gastroenterol. 2019 Oct 25. doi: 10.1007/s00535-019-01635-0. [Epub ahead of print] PubMed PMID: 31654131.
  3. Jono F, Iida H, Fujita K, Kaai M, Kanoshima K, Ohkuma K, Nonaka T, Ida T, Kusakabe A, Nakamura A, Koyama S, Nakajima A, Inamori M. Comparison of computed tomography findings with clinical risks factors for endoscopic therapy in upper gastrointestinal bleeding cases. J Clin Biochem Nutr. 2019 Sep;65(2):138-145. doi: 10.3164/jcbn.18-115. Epub 2019 Jun 28. PubMed PMID: 31592208; PubMed Central PMCID: PMC6769404.
  4. Ohkubo H, Yoshihara T, Misawa N, Ashikari K, Fuyuki A, Matsuura T, Higurashi T, Imajo K, Hosono K, Yoneda M, Kobayashi N, Saito S, Nakajima A. Relationship between Stool Form and Quality of Life in Patients with Chronic Constipation: An Internet Questionnaire Survey. Digestion. 2019 Oct 1:1-8. doi: 10.1159/000502815. [Epub ahead of print] PubMed PMID: 31574514.
  5. Sumida Y, Okanoue T, Nakajima A; Japan Study Group of NAFLD (JSG-NAFLD). Phase 3 drug pipelines in the treatment of non-alcoholic steatohepatitis. Hepatol Res. 2019 Sep 8. doi: 10.1111/hepr.13425. [Epub ahead of print] Review. PubMed PMID: 31495973.
  6. Kurita Y, Kuwahara T, Hara K, Mizuno N, Okuno N, Matsumoto S, Obata M, Koda H, Tajika M, Shimizu Y, Nakajima A, Kubota K, Niwa Y. Features of chronic pancreatitis by endoscopic ultrasound influence the diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration of small pancreatic lesions. Dig Endosc. 2019 Jul 30. doi: 10.1111/den.13497. [Epub ahead of print] PubMed PMID: 31361926.
  7. Umezawa S, Higurashi T, Komiya Y, Arimoto J, Horita N, Kaneko T, Iwasaki M, Nakagama H, Nakajima A. Chemoprevention of colorectal cancer: Past, present, and future. Cancer Sci. 2019 Oct;110(10):3018-3026. doi: 10.1111/cas.14149. Epub 2019 Sep 17. Review. PubMed PMID: 31361372; PubMed Central PMCID: PMC6778640.
  8. Chiba H, Tachikawa J, Arimoto J, Ashikari K, Kuwabara H, Nakaoka M, Goto T, Ohata K, Nakajima A. Predictive Factors of Mild and Severe Fibrosis in Colorectal Endoscopic Submucosal Dissection. Dig Dis Sci. 2019 Jul 16. doi: 10.1007/s10620-019-05735-y. [Epub ahead of print] PubMed PMID: 31312991.
  9. Arimoto J, Chiba H, Higurashi T, Fukui R, Tachikawa J, Misawa N, Ashikari K, Niikura T, Kuwabara H, Nakaoka M, Goto T, Nakajima A. Risk factors for incomplete polyp resection after cold snare polypectomy. Int J Colorectal Dis. 2019 Sep;34(9):1563-1569. doi: 10.1007/s00384-019-03347-6. Epub 2019 Jul 16. PubMed PMID: 31312890.
  10. Sakai E, Ohata K, Nakajima A, Matsuhashi N. Diagnosis and therapeutic strategies for small bowel vascular lesions. World J Gastroenterol. 2019 Jun 14;25(22):2720-2733. doi: 10.3748/wjg.v25.i22.2720. Review. PubMed PMID: 31235995; PubMed Central PMCID: PMC6580356.
  11. Matsuura T, Maru Y, Izumiya M, Hoshi D, Kato S, Ochiai M, Hori M, Yamamoto S, Tatsuno K, Imai T, Aburatani H, Nakajima A, Hippo Y. Organoid-based ex vivo reconstitution of Kras-driven pancreatic ductal carcinogenesis. Carcinogenesis. 2019 Jun 22. pii: bgz122. doi: 10.1093/carcin/bgz122. [Epub ahead of print] PubMed PMID: 31233118.
  12. Suzuki K, Yoneda M, Kobayashi N, Nakajima A. Neuroendocrine Tumor Treated with Arterial Chemoembolization Using DEB-TACE. Intern Med. 2019 Oct 1;58(19):2895-2896. doi: 10.2169/internalmedicine.2894-19. Epub 2019 Jun 7. PubMed PMID: 31178516; PubMed Central PMCID: PMC6815907.
  13. Honda Y, Imajo K, Kobayashi T, Kessoku T, Ogawa Y, Tomeno W, Yoneda M, Kobayashi N, Saito S, Nakajima A. Autotaxin is a valuable biomarker for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. Hepatol Res. 2019 Oct;49(10):1136-1146. doi: 10.1111/hepr.13382. Epub 2019 Jul 4. PubMed PMID: 31144415.
  14. Yoneda M, Ogawa Y, Imajo K, Nakajima A. Nonalcoholic fatty liver disease with advanced fibrosis as a multi-systemic disease: proceed with caution. Hepatobiliary Surg Nutr. 2019 Apr;8(2):170-172. doi: 10.21037/hbsn.2018.12.08. PubMed PMID: 31098371; PubMed Central PMCID: PMC6503254.
  15. Arimoto J, Chiba H, Tachikawa J, Goto T, Nakajima A. New inversion method: endoscopic submucosal dissection of a neoplasm extending into a colonic diverticulum. VideoGIE. 2019 Mar 12;4(5):230-231. doi: 10.1016/j.vgie.2019.01.006. eCollection 2019 May. PubMed PMID: 31061946; PubMed Central PMCID: PMC6492311.
  16. Kurita Y, Kuwahara T, Hara K, Mizuno N, Okuno N, Matsumoto S, Obata M, Koda H, Tajika M, Shimizu Y, Nakajima A, Kubota K, Niwa Y. Diagnostic ability of artificial intelligence using deep learning analysis of cyst fluid in differentiating malignant from benign pancreatic cystic lesions. Sci Rep. 2019 May 3;9(1):6893. doi: 10.1038/s41598-019-43314-3. PubMed PMID: 31053726; PubMed Central PMCID: PMC6499768.
  17. Nakajima A, Shinbo K, Oota A, Kinoshita Y. Polyethylene glycol 3350 plus electrolytes for chronic constipation: a 2-week, randomized, double-blind, placebo-controlled study with a 52-week open-label extension. J Gastroenterol. 2019 Sep;54(9):792-803. doi: 10.1007/s00535-019-01581-x. Epub 2019 Apr 22. PubMed PMID: 31011797; PubMed Central PMCID: PMC6698298.
  18. Nogami A, Yoneda M, Kobayashi T, Kessoku T, Honda Y, Ogawa Y, Suzuki K, Tomeno W, Imajo K, Kirikoshi H, Koide T, Fujikawa H, Saito S, Nakajima A. Assessment of 10-year changes in liver stiffness using vibration-controlled transient elastography in non-alcoholic fatty liver disease. Hepatol Res. 2019 Aug;49(8):872-880. doi: 10.1111/hepr.13349. Epub 2019 May 23. PubMed PMID: 30974498.
  19. Chan WK, Treeprasertsuk S, Goh GB, Fan JG, Song MJ, Charatcharoenwitthaya P, Duseja A, Dan YY, Imajo K, Nakajima A, Ho KY, Goh KL, Wong VW. Optimizing Use of Nonalcoholic Fatty Liver Disease Fibrosis Score, Fibrosis-4 Score, and Liver Stiffness Measurement to Identify Patients With Advanced Fibrosis. Clin Gastroenterol Hepatol. 2019 Nov;17(12):2570-2580.e37. doi: 10.1016/j.cgh.2019.03.006. Epub 2019 Mar 12. PubMed PMID: 30876959.
  20. Nakajima A, Taniguchi S, Kurosu S, Gillberg PG, Mattsson JP, Camilleri M. Efficacy, long-term safety, and impact on quality of life of elobixibat in more severe constipation: Post hoc analyses of two phase 3 trials in Japan. Neurogastroenterol Motil. 2019 May;31(5):e13571. doi: 10.1111/nmo.13571. Epub 2019 Feb 21. PubMed PMID: 30793431; PubMed Central PMCID: PMC6519041.
  21. Arimoto J, Higurashi T, Chiba H, Misawa N, Yoshihara T, Kato T, Kanoshima K, Fuyuki A, Ohkubo H, Nonaka T, Sato T, Sakai E, Iida H, Goto T, Nakajima A. Investigation of the Local Recurrence Rate after Colorectal Endoscopic Mucosal Resection: Is Incomplete Polyp Resection Really a Clinically Important Problem? Analysis of the Rationale for the "Resect and Discard" Strategy. Can J Gastroenterol Hepatol. 2019 Jan 8;2019:7243515. doi: 10.1155/2019/7243515. eCollection 2019. PubMed PMID: 30729100; PubMed Central PMCID: PMC6341238.
  22. Arimoto J, Chiba H, Ashikari K, Fukui R, Anan H, Tachikawa J, Suto T, Kawano N, Niikura T, Kuwabara H, Nakaoka M, Kato S, Ida T, Morohashi T, Goto T, Nakajima A. Safety of Cold Snare Polypectomy in Patients Receiving Treatment with Antithrombotic Agents. Dig Dis Sci. 2019 Nov;64(11):3247-3255. doi: 10.1007/s10620-019-5469-1. Epub 2019 Jan 25. PubMed PMID: 30684074.
  23. Kodama K, Kawaguchi T, Hyogo H, Nakajima T, Ono M, Seike M, Takahashi H, Nozaki Y, Kawanaka M, Tanaka S, Imajo K, Sumida Y, Kamada Y, Fujii H, Seko Y, Takehara T, Itoh Y, Nakajima A, Masaki N, Torimura T, Saibara T, Karino Y, Chayama K, Tokushige K. Clinical features of hepatocellular carcinoma in nonalcoholic fatty liver disease patients without advanced fibrosis. J Gastroenterol Hepatol. 2019 Sep;34(9):1626-1632. doi: 10.1111/jgh.14608. Epub 2019 Mar 6. PubMed PMID: 30668889.
  24. Fujii H, Imajo K, Yoneda M, Nakahara T, Hyogo H, Takahashi H, Hara T, Tanaka S, Sumida Y, Eguchi Y, Chayama K, Nakajima A, Nishimoto N, Kawada N; Japan Study Group of Nonalcoholic Fatty Liver Disease. HOMA-IR: An independent predictor of advanced liver fibrosis in nondiabetic non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 2019 Aug;34(8):1390-1395. doi: 10.1111/jgh.14595. Epub 2019 Feb 3. PubMed PMID: 30600551.
  25. Takagi Y, Kubota K, Takayanagi T, Kurita Y, Ishii K, Hasegawa S, Iwasaki A, Sato T, Fujita Y, Kato S, Kagawa K, Watanabe S, Sekino Y, Hosono K, Matsuhashi N, Yamanaka S, Iwao T, Yoshida K, Nakajima A. Clinical features of isolated proximal-type immunoglobulin G4-related sclerosing cholangitis. Dig Endosc. 2019 Jul;31(4):422-430. doi: 10.1111/den.13320. Epub 2019 Feb 11. PubMed PMID: 30570170.
  26. Tomeno W, Imajo K, Kuwada Y, Ogawa Y, Kikuchi M, Honda Y, Kato T, Kessoku T, Kirikoshi H, Yoneda M, Kitahora T, Saito S, Ozawa Y, Nakajima A. Distribution of liver stiffness in non-alcoholic fatty liver disease with higher fibrosis-4 index than low cut-off index. J Gastroenterol Hepatol. 2019 Aug;34(8):1411-1416. doi: 10.1111/jgh.14559. Epub 2019 Jan 6. PubMed PMID: 30506860.
  27. Kurita Y, Kobayashi N, Tokuhisa M, Goto A, Kubota K, Endo I, Nakajima A, Ichikawa Y. Sarcopenia is a reliable prognostic factor in patients with advanced pancreatic cancer receiving FOLFIRINOX chemotherapy. Pancreatology. 2019 Jan;19(1):127-135. doi: 10.1016/j.pan.2018.11.001. Epub 2018 Nov 10. PubMed PMID: 30473464.
  28. Ogawa Y, Yoneda M, Kobayashi T, Honda Y, Kessoku T, Imajo K, Saito S, Nakajima A. Present and emerging pharmacotherapies for non-alcoholic steatohepatitis in adults. Expert Opin Pharmacother. 2019 Jan;20(1):69-82. doi: 10.1080/14656566.2018.1543403. Epub 2018 Nov 9. Review. PubMed PMID: 30411635.
  29. Fukudo S, Miwa H, Nakajima A, Kinoshita Y, Kosako M, Hayashi K, Akiho H, Kuroishi K, Johnston JM, Currie M, Ohkusa T. High-dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double-blind, placebo-controlled study with a long-term open-label extension study in Japan. Neurogastroenterol Motil. 2019 Jan;31(1):e13487. doi: 10.1111/nmo.13487. Epub 2018 Oct 23. PubMed PMID: 30353619.
  30. Chiba H, Ohata K, Tachikawa J, Arimoto J, Ashikari K, Kuwabara H, Nakaoka M, Goto T, Nakajima A. Delayed Bleeding After Colorectal Endoscopic Submucosal Dissection: When Is Emergency Colonoscopy Needed? Dig Dis Sci. 2019 Mar;64(3):880-887. doi: 10.1007/s10620-018-5310-2. Epub 2018 Oct 3. PubMed PMID: 30284133.
  31. Yoneda M, Imajo K, Nakajima A. Will the magnetic resonance imaging proton density fat fraction replace liver biopsy as the gold standard for detecting steatosis? Hepatobiliary Surg Nutr. 2018 Aug;7(4):292-293. doi: 10.21037/hbsn.2018.04.02. PubMed PMID: 30221157; PubMed Central PMCID: PMC6131261.
  32. Komiya Y, Shimomura Y, Higurashi T, Sugi Y, Arimoto J, Umezawa S, Uchiyama S, Matsumoto M, Nakajima A. Patients with colorectal cancer have identical strains of Fusobacterium nucleatum in their colorectal cancer and oral cavity. Gut. 2019 Jul;68(7):1335-1337. doi: 10.1136/gutjnl-2018-316661. Epub 2018 Jun 22. PubMed PMID: 29934439; PubMed Central PMCID: PMC6582823.
  33. Hsu C, Caussy C, Imajo K, Chen J, Singh S, Kaulback K, Le MD, Hooker J, Tu X, Bettencourt R, Yin M, Sirlin CB, Ehman RL, Nakajima A, Loomba R. Magnetic Resonance vs Transient Elastography Analysis of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Pooled Analysis of Individual Participants. Clin Gastroenterol Hepatol. 2019 Mar;17(4):630-637.e8. doi: 10.1016/j.cgh.2018.05.059. Epub 2018 Jun 14. PubMed PMID: 29908362; PubMed Central PMCID: PMC6294709.
  34. Kato S, Honda K. CA19-9 as a therapeutic target in pancreatitis. Annals of Translational Medicine. 2019 | http://dx.doi.org/10.21037/atm.2019.09.161
  35. Kato S, Iwasaki A, Kurita Y, Arimoto J, Yamamoto T, Hasegawa S, Sato T, Imajo K, Hosono K, Kobayashi N, Yoneda M, Higurashi T, Kubota K, Utsunomiya D, Nakajima A. PLoS One. 2019 Dec 2;14(12):e0224921. doi: 10.1371/journal.pone.0224921. eCollection 2019. Three-dimensional analysis of pancreatic fat by fat-water magnetic resonance imaging provides detailed characterization of pancreatic steatosis with improved reproducibility.
  36. Comparison of prognosis between observation and surgical resection groups with small sporadic non-functional pancreatic neuroendocrine neoplasms without distant metastasis. Kurita Y, Hara K, Kuwahara T, Mizuno N, Okuno N, Haba S, Okuno M, Natsume S, Senda Y, Kubota K, Nakajima A, Niwa Y, Shimizu Y. J Gastroenterol. 2019 Dec 19. doi: 10.1007/s00535-019-01655-w. [Epub ahead of print] PMID: 31858231
  37. Up-Regulated MicroRNA-27b Promotes Adipocyte Differentiation via Induction of Acyl-CoA Thioesterase 2 Expression. Murata Y, Yamashiro T, Kessoku T, Jahan I, Usuda H, Tanaka T, Okamoto T, Nakajima A, Wada K. Biomed Res Int. 2019 Dec 10;2019:2916243. doi: 10.1155/2019/2916243. eCollection 2019. PMID: 31930115
  38. Effect of tofogliflozin and pioglitazone on hepatic steatosis in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: A randomized, open-label pilot study (ToPiND study). Ozaki A, Yoneda M, Kessoku T, Iwaki M, Kobayashi T, Honda Y, Ogawa Y, Imajo K, Sakai E, Taguri M, Yamanaka T, Iwasaki T, Kurihashi T, Saito S, Nakajima A. Contemp Clin Trials Commun. 2019 Dec 31;17:100516. doi: 10.1016/j.conctc.2019.100516. eCollection 2020 Mar. PMID: 31956725

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