「肝胆膵消化器病学」は横浜市立大学附属病院の消化器内科部門です


  1. Chiba H, Tachikawa J, Arimoto J, Ashikari K, Kuwabara H, Nakaoka M, Goto T, Higurashi T, Muramoto T, Ohata K, Nakajima A：(Multicenter Study)Endoscopic submucosal dissection of large pedunculated polyps with wide stalks: a retrospective multicenter study．Endoscopy　2021 Jan，53(1):77-80. doi: 10.1055/a-1194-4413. Epub 2020 Jul 9， PMID: 32645728 DOI: 10.1055/a-1194-4413．（2020 Jul 9. doi: 10.1055/a-1194-4413. Online ahead of print.）
  2. Takahashi H, Nakahara T, Kogiso T, Imajo K, Kessoku T, Kawaguchi T, Ide T, Kawanaka M, Hyogo H, Fujii H, Ono M, Kamada Y, Sumida Y, Anzai K, Shimizu M, Torimura T, Nakajima A, Tokushige K, Chayama K, Eguchi Y; Japan Study Group of NAFLD (JSG‐NAFLD).：(Original Article)Eradication of hepatitis C virus with direct-acting antivirals improves glycemic control in diabetes: A multicenter study．JGH Open. 2020 Dec 19;5(2):228-234. doi: 10.1002/jgh3.12474. eCollection 2021 Feb. PMID: 33553660 PMCID: PMC7857302．
  3. Eiji Yamada , Seishi Tsunoda , Masumi Mimura , Masashi Akizuki , Yoichiro Miyazawa , Toshihiro Yamazaki, Yasuhiko Nagano, Reiko Murakami , Takashi Kitahara , Junichi Wakasugi , Yukihiro Ozawa , Tatsuji Komatsu , Masahiko Inamori , Kazuki Nagai , Atsushi Nakajima : Positioning of Bristol Stool Form Scale type 3 in constipation treatment satisfaction: A multicenter study in Japan．Journal of Gastroenterology and Hepatology; 2021 Aug;36(8):2125-2130. doi: 10.1111/jgh.15428. Epub 2021 Feb 10.PMID: 33538361.
  4. Yagi S, Kurita Y, Nakajima A： Removal of pancreatic stones stuck in basket catheter with peroral pancreatoscopy and electronic hydraulic lithotripsy．Dig Endosc (Digestive Endoscopy)2021 Jan，33(1):e14-e15. doi: 10.1111/den.13874. Epub 2020 Nov 30. PMID: 33251602 DOI: 10.1111/den.13874.
  5. Takashi Kobayashi , Takaomi Kessoku , Anna Ozaki , Michihiro Iwaki , Yasushi Honda , Yuji Ogawa , Kento Imajo , Masato Yoneda , Satoru Saito , Atsushi Nakajima：Vitamin B6 efficacy in the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, single-center trial．J Clin Biochem Nutr，2021 Mar;68(2):181-186. PMID: 33879971 PMCID: PMC8046002 doi: 10.3164/jcbn.20-142. Epub 2021 Jan 16.
  6. Kawashima Keigo,Isogawa Masanori,Onishi Masaya,Lan Baudi,Saito Satoru,Nakajima Atsushi,Fujita Takashi,Tanaka Yasuhiro: Restoration of type I interferon signaling in intrahepatically primed CD8+ T cells promotes functional differentiation,JCI insight, 2021 Feb 8;6(3):e145761. doi: 10.1172/jci.insight.145761.（Received: November 4, 2020; Accepted: December 23, 2020），PMID: 33400688 PMCID: PMC7934883.
  7. Shigeta Miyake, Keiichi Ashikari,Shingo Kato,Tomohiro Takatsu, Hirofumi Kuwashima, Hiroaki Kaneko,Koki Nagai, Ikue Watari,Takamitsu Sato, Yutaro Yamaoka,Tetsuya Yamamoto, Akihide Ryo, Shin Maeda,Atsushi Nakajima,Takuma Higurashi：SARS‐CoV‐2 prevalence in saliva and gastric and intestinal fluid in patients undergoing gastrointestinal endoscopy in COVID‐19 endemic areas: prospective cross‐sectional study in Japan.Digestive Endoscopy, https://doi.org/10.1111/den.13945. First published: 06 February 2021.
  8. Yoshio Sumida , Masashi Yoneda , Katsutoshi Tokushige, Miwa Kawanaka, Hideki Fujii , Masato Yoneda , Kento Imajo , Hirokazu Takahashi , Yuichiro Eguchi , Masafumi Ono , Yuichi Nozaki , Hideyuki Hyogo , Masahiro Koseki , Yuichi Yoshida , Takumi Kawaguchi , Yoshihiro Kamada , Takeshi Okanoue , Atsushi Nakajima ，（ Japan Study Group of NAFLD (JSG-NAFLD)）： FIB-4 First in the Diagnostic Algorithm of Metabolic-Dysfunction-Associated Fatty Liver Disease in the Era of the Global Metabodemic． Life 2021, 11(2), 143; https://doi.org/10.3390/life11020143，Received: 9 January 2021 / Revised: 22 January 2021 / Accepted: 25 January 2021 / Published: 14 February 2021．
  9. Jun Tachikawa, Hideyuki Chiba, Naoya Okada, Jun Arimoto , Keiichi Ashikari , Hiroki Kuwabara, Michiko Nakaoka, Takuma Higurashi, Toru Goto，Atsushi Nakajima：(Research article)Impact of obesity in colorectal endoscopic submucosal dissection: single-center retrospective cohort study．BMC Gastroenterol 2021 Feb 16;21(1):74. doi: 10.1186/s12876-021-01652-5.PMID: 33593282. PMCID: PMC7885483.
  10. Iwaki M, Kessoku T, Ozaki A, Kasai Y, Kobayashi T, Nogami A, Honda Y, Ogawa Y, Imajo K, Yoneda M, Maeda A, Tanaka Y, Nakajima S, Ohno H, Usuda H, Kawanaka M, Kawaguchi T, Torimura T, Kage M, Hyogo H, Takahashi H, Eguchi Y, Aishima S, Wada K, Kobayash N, Sumida Y, Saito S, Nakajima A：Gut microbiota composition associated with hepatic fibrosis in non-obese patients with non-alcoholic fatty liver disease.J Gastroenterol Hepatol. 2021 Aug ;36(8) doi: 10.1111/jgh.15487. Online ahead of print.PMID: 33709477.Epub 2021 Mar 29.
  11. Abdelmalek MF, Charles ED, Sanyal AJ, Harrison SA, Neuschwander-Tetri BA, Goodman Z, Ehman RA, Karsdal M, Nakajima A, Du S, Tirucherai GS, Klinger GH, Mora J, Yamaguchi M, Shevell DE, Loomba R ：The FALCON program: Two phase 2b randomized, double-blind, placebo-controlled studies to assess the efficacy and safety of pegbelfermin in the treatment of patients with nonalcoholic steatohepatitis and bridging fibrosis or compensated cirrhosis.Contemp Clin Trials. 2021 May;104:106335. doi: 10.1016/j.cct.2021.106335. Epub 2021 Feb 28. Online ahead of print.PMID: 33657443．
  12. Imajo K, Tetlow L, Dennis A, Shumbayawonda E, Mouchti S, Kendall TJ, Fryer E, Yamanaka S, Honda Y, Kessoku T, Ogawa Y, Yoneda M, Saito S, Kelly C, Kelly MD, Banerjee R, Nakajima A：(Observational Study)Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort.World J Gastroenterol. 2021 Feb 21;27(7):609-623. doi: 10.3748/wjg.v27.i7.609.PMID: 33642832 Free PMC article.
  13. Okanoue T, Shima T, Mitsumoto Y, Umemura A, Yamaguchi K, Itoh Y, Yoneda M, Nakajima A, Mizukoshi E, Kaneko S, Harada K ：Artificial intelligence/neural network system for the screening of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.Hepatol Res. 2021 May;51(5):554-569. doi: 10.1111/hepr.13628. First published:2021 Feb 16. Online ahead of print.PMID: 33594747. Epub 2021 Mar 20.
  14. Jun Arimoto, Ken Ohata , Hideyuki Chiba , Jun Tachikawa , Naoya Okada , Hiroki Kuwabara , Michiko Nakaoka , Keiichi Ashikari , Rindo Ishii , Yohei Minato , Maiko Takita , Eiji Sakai , Takashi Muramoto , Nobuyuki Matsuhashi , Tohru Goto , Atsushi Nakajima：Evaluation of colorectal endoscopic submucosal dissection using a multifunctional snare: a prospective clinical feasibility study (with videos)．Gastrointest Endosc. 2021 Mar;93(3):671-678. doi: 10.1016/j.gie.2020.09.019. Epub 2020 Sep 18. PMID: 32950596．
  15. Cayden Beyer,Chloe Hutton,Anneli Andersson,Kento Imajo,Atsushi Nakajima,Dustin Kiker,Rajarshi Banerjee,Andrea Dennis：Comparison between magnetic resonance and ultrasound-derived indicators of hepatic streatosis in a pooled NAFLD cohort.PLoS One.2021 Apr 1;16(4):e0249491.doi:10.1371/journal.pone.0249491.eCollection 2021.PMID:33793651 PMCID:PMC8016312.
  16. Masato Yoneda,Yasushi Honda,Satoru Saito,Atsushi Nakajima: What considerations are there for the pharmacotherapeutic management of nonalcoholic steatohepatitis?. Expert　Opin Pharmacother ,Received 22 Dec 2020, Accepted 29 Mar 2021, 2021 Apr 21;1-4. doi: 10.1080/14656566.2021.1912014. Online ahead of print.doi:10.1080/14656566.2021.1912014,PMID:33880982.
  17. Kato Shingo, Fushimi Kentaro,Yabuki Yuichiro,Maru Yoshiaki,Hasegawa Sho,Matsuura Tetsuya,Kurotaki Daisuke,Suzuki Akihiro,Kobayashi Noritoshi,Yoneda Msato,Takuma Higurashiakuma,Enaka Makiko,Tamura Tomohiko,Hippo Yoshitaka,Nakajima Atsushi:Precision modeling of gall bladder cancer patients in mice based on orthotopic implantation of organoid-derived tumor buds. Oncogenesis，10(4):33，PMID:33866327 PMCID:PMC8053198 doi: 10.1038/s41389-021-00322-1，2021 Apr 17.
  18. Hiroshi Ishiba,Yoshio Sumida,Yuya Seko, Saiyu Tanaka, Masato Yoneda, Hideyuki Hyogo, Masafumi Ono, Hideki Fujii, Yuichiro Eguchi, Yasuaki Suzuki,Masashi Yoneda, Hirokazu Takahashi, Takashi Nakahara, Kojiro Mori, Kazuyuki Kanemasa, Keiji Shimada, Kento Imajo, Kanji Yamaguchi, Takumi Kawaguchi, Atsushi Nakajima, Kazuaki Chayama, Toshihide Shima, Kazuma Fujimoto, Takeshi Okanoue, Yoshito Itoh, and the Japan Study Group of NAFLD：Type IV Collagen 7S Is the Most Accurate Test For Identifying Advanced Fibrosis in NAFLD With Type 2 Diabetes．Hepatol Commun　2021 Apr; 5(4): 559–572，Published online 2020 Nov 16，doi: 10.1002/hep4.1637 PMID: 33860115 PMCID: PMC8034577 DOI:，eCollection 2021 Apr.
  19. Ferenc Emil Mózes, Jenny A Lee, Emmanuel Anandraj Selvaraj, Arjun Narayan Ajmer Jayaswa, Michael Trauner, Jerome Boursier, Céline Fournier, Katharina Staufer, Rudolf E Stauber, Elisabetta Bugianesi,Ramy Younes, Silvia Gaia, Monica Lupșor-Platon, Salvatore Petta, Toshihide Shima, Takeshi Okanoue, Sanjiv Mahadeva, Wah-Kheong Chan, Peter J Eddowes, Gideon M Hirschfield,　Philip Noel Newsome, Vincent Wai-Sun Wong, Victor de Ledinghen, Jiangao Fan, Feng Shen, Jeremy F Cobbold, Yoshio Sumida, Akira Okajima, Jörn M Schattenberg, Christian Labenz, Won Kim, Myoung Seok Lee, Johannes Wiegand,Guruprasad Padur Aithal, Naaventhan Palaniyappan1, Christophe Cassinotto, Sandeep Aggarwal, Harshit Garg, XGeraldine J Ooi, Atsushi Nakajima, Masato Yoneda, Marianne Ziol, Nathalie Barget,Andreas Geier, Theresa Tuthill, M. Julia Brosnan, Quentin Mark Anstee, Stefan Neubauer, Stephen A. Harrison, Patrick M Bossuyt, Michael Pavlides，（LITMUS　Investigators）：Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis．J Hepatol.;75(4) :770-785( S0168-8278(21)00309-3). PMID: 33991635 doi: 10.1016/j.jhep.2021.04.044. Online ahead of print　2021 May 13.
  20. Kaai M, Inamori M, Matsuura M, Iwata Y, Iida H, Fujita K, Kusakabe A, Nakajima A：Early effects of acotiamide or mosapride intake on gastric emptying: a randomized 3-way crossover study using the 13 C breath test．(Case Report)J Clin Bipchem Nutr(Journal of Clinical biochemistry and nutrition)， 2021 May;68(3):264-267. doi: 10.3164/jcbn.20-162. Epub 2021 Feb 5. PMID: 34025031 PMCID: PMC8129981 DOI: 10.3164/jcbn.20-162.
  21. Miyake　Shigeta， Takuma Higurashiakuma ， Jono　Takashi，Akimoto, Taisuke， Ogawa　Fumihiro，Yasufumi，Tanaka Katsushi, Hara Yu, Kobayashi Nobuaki,Kato Hideaki, Yamashiro Tsuneo, Utsunomiya Daisuke Nakajima Atsushi, Yamamoto Tetsuya, Maeda Shin, Kaneko Takeshi , Takeuchi Ichiro:Real-world evaluation of a computed tomography-first triage strategy for suspected Coronavirus disease 2019 in outpatients in Japan　An observational cohort study. Medicine (Baltimore)，100(22):e26161. PMID34087874　PMCIDPMC8183760　doi: 10.1097/MD.0000000000026161，2021　Jun 4.
  22. Sho Hasegawa, Masato Yoneda, Yusuke Kurita, Asako Nogami, Yasushi Honda, Kunihiro Hosono，Atsushi Nakajima: （Review） Cholestatic Liver Disease: Current Treatment Strategies and New Therapeutic Agents．Drugs(2021 Jul), ;81(10):1181-1192. doi: 10.1007/s40265-021-01545-7. Epub 2021 Jun 17. PMID: 34142342，PMCID: PMC8282588
  23. Kurita Yusuke,Fujita Yuji,Sekino Ysuke,Watanabe Seitaro,Iwasaki Akito,Kagawa Koichi,Tanida Emiko,Yagi Shin,Hasegawa Sho,Sato Takamitsu,Hosono Kunihiro,Kato Shingo,Kobayashi Noritoshi,Ichikawa Yasushi,Endo Itaru,Nakajima Atsushi,Kubota Kensuke: IgG4-related sclerosing cholangitis may be a risk factor for cancer．J Hepatobiliary Pancreat Sci(Journal of Hepato-Biliary-Pancreatic Sciences). 2021 Jun;28(6):524-532. doi: 10.1002/jhbp.957. Epub 2021 May 24. PMID: 33931982(First published: 30 April 2021)
  24. Kessoku T, Kobayashi T, Tanaka K, Yamamoto A, Takahashi K, Iwaki M, Ozaki A, Kasai Y, Nogami A, Honda Y, Ogawa Y, Kato S, Imajo K, Takuma Higurashi, Hosono K, Yoneda M, Usuda H, Wada K, Saito S, Nakajima A：The Role of Leaky Gut in Nonalcoholic Fatty Liver Disease: A Novel Therapeutic Target．International Journal of Molecular Sciences, 22(15):8161， PMID: 34360923 PMCID: PMC8347478 doi: 10.3390/ijms22158161，2021 Jul 29.
  25. Yasser Fouad,Jeffrey V Lazarus,Francesco Negro,Markus Peck-Radosavljevic,Shiv K Sarin,Peter Ferenci,Gamal Esmat,Hasmilk Ghazinian,Nakajima Atsushi,Marcelo Silva,Samuel Lee,Massimo Colombo: MAFLD considerations as a part of the global hepatitis C elimination effort: an international perspective．Aliment Pharmacol Ther(Alimentary Pharmacology & Therapeutics). 2021 May;53(10):1080-1089. doi: 10.1111/apt.16346. Epub 2021 Mar 22. PMID: 33751604.
  26. Okanoue T, Shima T, Mitsumoto Y, Umemura A, Yamaguchi K, Itoh Y, Yoneda M, Nakajima A, Mizukoshi E, Kaneko S, Harada K:(Original article) Novel artificial intelligent/neural network system for staging of nonalcoholic steatohepatitis. Hepatol Res.(Hepatology Research), 2021 Oct;51(10):1044-1057. PMID: 34124830 doi: 10.1111/hepr.13681. Epub 2021 Jun 30.
  27. Keiichi Ashikari, Nonaka T, Takuma Higurashi, Tomohiro Takatsu, Tsutomu Yoshihara, Noboru Misawa, Arimoto J, Kanoshima K, Matsuura T, Fuyuki A, Ohkubo H, Chiba H, Nakajima A: Efficacy of sedation with dexmedetomidine plus propofol during esophageal endoscopic submucosal dissection. J Gastroenterol Hepatol(Journal of gastroenterology and hepatology), 2021 Jul, 36(7):1920-1926. doi: 10.1111/jgh.15417. Epub 2021 Feb 4. PMID: 33506496.
  28. Tanabe H, Takuma Higurashi, Tomohiro Takatsu, Noboru Misawa, Tsutomu Yoshihara, Goto S, Arimoto J, Keiichi Ashikari, Taniguchi L, Chiba H, Nakajima A. Effects of colorectal endoscopic submucosal dissection on postoperative abdominal symptoms: a prospective observational study: Surgical Endoscopy. 2022 Jan;36(1):314-320　PMID: 33502617　doi: 10.1007/s00464-020-08278-w. Online ahead of print. Epub 2021 Jan 27．
  29. Ozaki A, Kessoku T, Kasai Y, Takeda Y, Okubo N, Iwaki M, Kobayashi T, Tsutomu Yoshihara, Honda Y, Fuyuki A, Takuma Higurashi, Ishiki H, Taguri M, Oyamada S, Kobayashi N, Nakajima A, Ichikawa Y：Elobixibat Effectively Relieves Chronic Constipation in Patients with Cancer Regardless of the Amount of Food Intake．Oncologist 2021 Jun 27，26(10):e1862-e1869,2021 doi:10.1002/onco.13879. Online ahead of print.PMID: 34180099．
  30. Tada T, Saibara T, Ono M, Takahashi H, Eguchi Y, Hyogo H, Kawanaka M, Kumada T, Toyoda H, Yasuda S, Nakajima A, Yoneda M, Tanaka S, Shimada K, Hoshino H, Aishima S, Kage M, Sumida Y：（Original 　Article）Predictive value of cytokeratin-18 fragment levels for diagnosing steatohepatitis in patients with nonalcoholic fatty liver disease．European Journal of Gastroenterology & Hepatology, 33(11):1451-1458. PMID: 34334708 doi: 10.1097/MEG.0000000000002176，2021 Nov 1．
  31. Hasegawa S, Koshita S, Kanno Y, Ogawa T, Sakai T, Kusunose H, Kubota K, Nakajima A, Noda Y, Ito K：（Original Article）Endoscopic Interventions for the Early and Remission Phases of Acute Biliary Pancreatitis: What are the More Concrete and Practical Situations for Performing Them? Clin Endosc 2021 Nov;54(6):888-898. PMID: 34038997　PMCID: PMC8652157　doi: 10.5946/ce.2020.271. Online ahead Clin Endosc，Epub 2021 May 27．
  32. Imajo K, Kessoku T, Honda Y, Hasegawa S, Tomeno W, Ogawa Y, Motosugi U, Saigusa Y, Yoneda M, Kirikoshi H, Yamanaka S, Utsunomiya D, Saito S, Nakajima A：（Research Article）MRI-Based Quantitative R2 * Mapping at 3 Tesla Reflects Hepatic Iron Overload and Pathogenesis in Nonalcoholic Fatty Liver Disease Patients．J Magn Reson Imaging(Journal of Magnetic Resonancs Imaging)．2022 Jan;55(1):111-125　 PMID: 34184822　doi: 10.1002/jmri.27810. Online ahead of print，Epub 2021 June 28.
  33. Yoneda M, Honda Y, Ogawa Y, Kessoku T, Kobayashi T, Imajo K, Ozaki A, Nogami A, Taguri M, Yamanaka T, Kirikoshi H, Iwasaki T, Kurihashi T, Saito S, Nakajima A：（Randomized Controlled Trial） Comparing the effects of tofogliflozin and pioglitazone in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus (ToPiND study): a randomized prospective open-label controlled trial．BMJ　Open Diabetes Res Care 2021 Feb;9(1):e001990. doi: 10.1136/bmjdrc-2020-001990. PMID: 33593749 PMCID: PMC7888333，2021 Feb．
  34. Sho Hasegawa,Kensuke Kubota,Shin Yagi,Yusuke Kurita,Takamitsu Sato,Kunihiro Hosono,Ryusei Matsuyama,Itaru Endo,Noritoshi Kobayashi,Atsushi Nakajima：（Original Aricle）Covered metallic stent placement for biliary drainage could be promising in the coming era of neoadjuvant chemo-radiation therapy for all pancreatic cancer．Journal of Hepato-Biliary-Pancreatic Sciences 2021 Jul，28(7)：617-624　First published: 31 March 2021 PMID:33788414 doi.org/10.1002/jhbp.958,Epub 2021 Apr 19.
  35. Ferenc Emil Mózes, Jenny A Lee, Emmanuel Anandraj Selvaraj, Arjun Narayan Ajmer Jayaswal, Michael Trauner, Jerome Boursier, Céline Fournier, Katharina Staufer, Rudolf E Stauber, Elisabetta Bugianesi, Ramy Younes, Silvia Gaia, Monica Lupșor-Platon, Salvatore Petta, Toshihide Shima, Takeshi Okanoue, Sanjiv Mahadeva, Wah-Kheong Chan, Peter J Eddowes, Gideon M Hirschfield, Philip Noel Newsome, Vincent Wai-Sun Wong, Victor de Ledinghen, Jiangao Fan, Feng Shen, Jeremy F Cobbold, Yoshio Sumida, Akira Okajima, Jörn M Schattenberg, Christian Labenz, Won Kim, Myoung Seok Lee, Johannes Wiegand, Thomas Karlas, Yusuf Yılmaz, Guruprasad Padur Aithal, Naaventhan Palaniyappan, Christophe Cassinotto, Sandeep Aggarwal, Harshit Garg, Geraldine J Ooi, Atsushi Nakajima, Masato Yoneda, Marianne Ziol, Nathalie Barget, Andreas Geier, Theresa Tuthill, M Julia Brosnan, Quentin Mark Anstee, Stefan Neubauer, Stephen A Harrison, Patrick M Bossuyt, Michael Pavlides, LITMUS Investigators: Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut，2022 May;71(5):1006-1019. PMID: 34001645 PMCID: PMC8995830 doi: 10.1136/gutjnl-2021-324243.Epub　2021 May 17．
  36. Shigeta Miyake,Takuma Higurashi,Hideaki Kato,Yutaro Yamaoka,Takaomi Kessoku,Shingo Ｋato,Fumihiro Ogawa,Yasufumi Oi,Atsushi Nakajima,Tesuya Yamamoto,Ichiro Takeuchi,Akihide Ryo, Shin Maeda: Evaluation of a combination protocol of CT-first triage and active telemedicine methods by a selected team tackling COVID-19: An experimental research study.Journal of Infection and Public Health,September 2021,14(9),1212-1217, PMID:34425358 PMCID:PMC8372458 doi: 10.1016/j.jiph.2021.08.016. Epub 2021 Aug 18.
  37. Noriko Nishimiya, Kazuki Tajima, Kento Imajo, Akiko Kameda, Eiko Yoshida, Yu Togashi, Kazutaka Aoki, Tomio Inoue, Atsushi Nakajima, Daisuke Utsunomiya, Yasuo Terauchi：Effects of Canagliflozin on Hepatic Steatosis, Visceral Fat and Skeletal Muscle among Patients with Type 2 Diabetes and Non-alcoholic Fatty Liver Disease．Intern Med．2021 Nov 1;60(21):3391-3399. 2021 May 14. PMID: 33994437　PMCID: PMC8627812 doi: 10.2169/internalmedicine.7134-21. Online ahead of print. Epub 2021 May 14.
  38. Akiko Fuyuki, Takuma Higurashi, Takaomi Kessoku, Keiichi Ashikari, Tsutomu Yoshihara, Noboru Misawa, Michihiro Iwaki, Takashi Kobayashi, Hidenori Ohkubo, Masato Yoneda, Haruki Usuda, Koichiro Wada, Atsushi Nakajima：Efficacy of Bifidobacterium bifidum G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study．Biosci Microbiota Food Health， 2021;40(2):105-114. doi: 10.12938/bmfh.2020-073. PMID: 33996367 PMCID: PMC8099630， Epub 2021 Jan 19.
  39. Yasushi Honda, Anna Ozaki, Michihiro Iwaki, Takashi Kobayashi, Asako Nogami, Takaomi Kessoku, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Masato Yoneda, Satoru Saito, Yoji Nagashima, Atsushi Nakajima：Protective effect of SGL5213, a potent intestinal sodium-glucose cotransporter 1 inhibitor, in nonalcoholic fatty liver disease in mice．J Pharmacol Sci， 2021 Oct;147(2):176-183. doi: 10.1016/j.jphs.2021.07.002. PMID: 34384565， Epub 2021 Jul 8.
  40. Michihiro Iwaki,Takaomi Kessoku,Taro Kanamori,Kentaro Abe,Nobuhiro Takeno,Ryoko Kawahara,Taisuke Fujimoto,Takashi Igarashi,Yasutomo Kumakura,Naoki Suzuki,Kouhei Kamiya,Naoto Suzuki,Keita Tagami,Tomoya Saeki,Hironori Mawatari,Hiroki Sakurai,Takahiro Higashibata,Takeshi Hirohashi,Atsushi Nakajima,Yasushi Ichikawa,Hiroto Ishiki, Palliative-Care Investigators’ Network in Kanto (PINK): Tapentadol Safety and Patient Characteristics Associated with Treatment Discontinuation in Cancer Therapy: A Retrospective Multicentre Study in Japan. Pain and Ther, 2021 Dec;10(2):1635-1648. PMID: 34581982 PMCID: PMC8586125　doi: 10.1007/s40122-021-00327-z. Online ahead of print, Received: July 17, 2021 / Accepted: September 10, 2021. Epub 2021 Sep 28.
  41. Kento Kuzuu, Noboru Misawa, Keiichi Ashikari, Takaomi Kessoku, Shingo Kato, Kunihiro Hosono, Masato Yoneda, Takashi Nonaka, Shozo Matsushima, Tatsuji Komatsu, Atsushi Nakajima, Takuma Higurashi：Gastrointestinal Cancer Stage at Diagnosis Before and During the COVID-19 Pandemic in Japan．JAMA Netw Open, 2021 Sep 1;4(9):e2126334. PMID: 34546368 PMCID: PMC8456386　doi:10.1001/jamanetworkopen.2021.26334.
  42. Atsushi Nakajima, Yuichiro Eguchi, Masato Yoneda, Kento Imajo, Nobuharu Tamaki, Hideki Suganami, Toshiaki Nojima, Ryohei Tanigawa, Masakazu Iizuka, Yuki Iida, Rohit Loomba: Randomised clinical trial: Pemafibrate, a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), versus placebo in patients with non-alcoholic fatty liver disease．Aliment Pharmacol Ther．(Alimentary Pharmacology & Therapeutics) 2021 Nov, 54(10):1263-1277. PMID: 34528723　doi: 10.1111/apt.16596, Epub 2021 Sep 16．
  43. Koki Meguro, Kunihiro Hosono, Motokazu Sato, Yuichi Sugimoto, Yusuke Takai, Yusuke Kurita, Kenji Kanoshima, Tomoki Shimizu, Eiji Sakai, Atsushi Nakajima：Prognostic Impact of Sarcopenia in Patients With Biliary Tract Cancer Undergoing Chemotherapy．In Vivo， Sep-Oct 2021;35(5):2909-2915. PMID: 34410986　PMCID: PMC8408710 doi: 10.21873/invivo.12581.
  44. Kento Imajo, Hidenori Toyoda, Satoshi Yasuda, Yasuaki Suzuki, Katsutoshi Sugimoto, Hidekatsu Kuroda, Tomoyuki Akita, Junko Tanaka, Yutaka Yasui, Nobuharu Tamaki, Masayuki Kurosaki, Namiki Izumi,Atsushi Nakajima, Takashi Kumada：Utility of ultrasound-guided attenuation parameter for grading steatosis with reference to MRI-PDFF in a large cohort．Clinical Gastroenterology and Hepatology ，2022 Nov;20(11):2533-2541.e7.S1542-3565(21)01182-4. PMID: 34768008 doi: 10.1016/j.cgh.2021.11.003，Epub　2021 Nov 10.
  45. Goto S, Arimoto J, Takuma Higurashi, Takahashi K, Ohkubo N, Kawamura N, Tamura T, Tomonari H, Iwasaki A, Taniguchi L, Chiba H, Atsukawa K, Saigusa Y, Nakajima A：Efficacy and safety of colorectal endoscopic submucosal dissection in patients with sarcopenia，Surgical endoscopy, 35(10):5489-5496. doi: 10.1007/s00464-020-08041-1，PMID: 32989535　DOI: 10.1007/s00464-020-08041-1，P，2021　Oct Epub 2020 Sep.
  46. Sho Hasegawa, Itaru Endo, Kensuke Kubota: Plastic or self-expandable metal stent: Which is the most suitable for patients with pancreatic head cancer in the upcoming era of neoadjuvant chemotherapy? A review. Digestive Endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 2022 Jan;34(2):297-306. PMID: 34388286 doi: 10.1111/den.14107. Epub 2021 Aug 27.
  47. Sumida Y, Yoneda M, Seko Y, Takahashi H, Hara N, Fujii H, Itoh Y, Yoneda M, Nakajima A, Okanoue T; Japan Study Group of NAFLD (JSG-NAFLD): Role of vitamin E in the treatment of non-alcoholic steatohepatitis.Free radical biology & medicine, 177:391-403. PMID: 34715296 doi: 3410.1016/j.freeradbiomed.2021.10.017. Epub 2021 Oct 29.
  48. Takahashi H, Kessoku T, Kawanaka M, Nonaka M, Hyogo H, Fujii H, Nakajima T, Imajo K, Tanaka K, Kubotsu Y, Isoda H, Oeda S, Kurai O, Yoneda M, Ono M, Kitajima Y, Tajiri R, Takamori A, Kawaguchi A, Aishima S, Kage M, Nakajima A, Eguchi Y, Anzai K：Ipragliflozin Improves the Hepatic Outcomes of Patients With Diabetes with NAFLD． Hepatology Communications, 2022 Jan;6(1):120-132. PMID: 34558835 PMCID: PMC8710792 doi: 10.1002/hep4.1696. Epub 2021 Jun 17.
  49. Inoue T, Funatsu Y, Ohnishi M, Isogawa M, Kawashima K, Tanaka M, Moriya K, Kawaratani H, Momoda R, Iio E, Nakagawa H, Suzuki Y, Matsuura K, Fujiwara K, Nakajima A, Yoshiji H, Nakayama J, Tanaka Y：Bile acid dysmetabolism in the gut-microbiota-liver axis under hepatitis C virus infection．Liver international, 2022 Jan;42(1):124-134 PMID: 34411400 DOI: 10.1111/liv.15041, 2021 Aug 19 Online ahead of print　Epub 2021 Sep 5.
  50. Anneli Andersson,Matt Kelly,Kento Imajo,Atsushi Nakajima,Jonathan A.Fallowfield, Gideon Hirschfield, Michael Pavlides, Arun J.Sanya, Mazen Noureddin,Rajarshi Banerjee,Andrea Dennis, Stephen Harrison: Clinical utility of MRI biomarkers for identifying NASH patients’ high risk of progression: A multi-center pooled data and meta-analysis．Clinical Gastroenterology and Hepatology  2022 Nov;20(11):2451-2461.e3.; PMID:34626833 https://doi.org/10.1016/j.cgh.2021.09.041，Epub 2021 Oct 7．
  51. Eunice Xiang-Xuan Tan, Jonathan Wei-Jie Lee, Nur Halisah Jumat, Wah-Kheong Chan, Sombat Treeprasertsuk, George Boon-Bee Goh, Jian-Gao Fan, Myeong Jun Song, Phunchai Charatcharoenwitthaya, Ajay Duseja, Kento Imajo, Atsushi Nakajima, Yosuke Seki, Kazunori Kasama, Satoru Kakizaki, Laurentius A Lesmana, Kenneth I Zheng, Ming-Hua Zheng, Calvin J Koh, Khek-Yu Ho, Khean-Lee Goh, Vincent Wai-Sun Wong, Yock-Young Dan：Non-obese non-alcoholic fatty liver disease (NAFLD) in Asia: an international registry study．Metabolism(January 2022)，126:154911. PMID: 34648769 doi: 10.1016/j.metabol.2021.154911， 2021 Oct 12 Online ahead of print.
  52. Kakegawa T, Sugimoto K, Kuroda H, Suzuki Y, Imajo K, Toyoda H; GITHY Liver Study Group(Nobuharu Tamaki, Satoshi Yasuda, Yutaka Yasui, Masayuki Kurosaki, Namiki Izumi, Atsushi Nakajima, Takashi Kumada)：Diagnostic Accuracy of Two-Dimensional Shear Wave Elastography for Liver Fibrosis: A Multicenter Prospective Study.Clinical gastroenterology and hepatology 2022 Jun;20(6):e1478-e1482,PMID: 34425275　doi: 10.1016/j.cgh.2021.08.021， 2021 Aug　20 Online ahead of print.
  53. Tamaki N, Imajo K, Sharpton S, Jung J, Kawamura N, Yoneda M, Valasek MA, Behling C, Sirlin CB, Nakajima A, Loomba R: MRE plus FIB-4 (MEFIB) versus FAST in detection of candidates for pharmacological treatment of NASH-related fibrosis．Hepatology　2022 Mar;75(3):661-672. PMID: 34496054 doi: 10.1002/hep.32145. Epub 2021 Dec 15.
  54. Shao Xue，Uojima H，Arai T，Ogawa Y，Setsu T，Atsukawa M，Furuichi Y，Arase Y，Horio K，Hidaka H，Nakazawa T，Kako M，Kagawa T，Iwakiri K，Nakajima A，Terai S，Tanaka Y，Koizumi W：The risk of cirrhosis and its complications based on PNPLA3 rs738409 G allele frequency．Dig Dis.(Digestive disease(Basel,Switzerland) 2022;40(5):625-634, PMID: 34808618　doi:10.1159/000521062, Epub 2021 Nov 22.
  55. Hidetoshi Kitamura, Susumu Hijioka, Yoshikuni Nagashio, Shunsuke Sugawara, Satoshi Nara, Miyuki Sone, Minoru Esaki, Yasuaki Arai, Takuji Okusaka, Atsushi Nakajima：Use of endoscopic ultrasound-guided biliary drainage as a rescue of re-intervention after the placement of multiple metallic stents for malignant hilar biliary obstruction．Journal of hepato-biliary-pancreat sciences 2022 Mar;29(3):404-414, PMID: 34661973　doi: 10.1002/jhbp.1059. Epub 2021 Nov 18.
  56. Yoneda Masato, Yamamoto Takuma, Honda Yasushi, Imajo Kento, Ogawa Y, Kessoku Takaomi, Kobayashi Takashi, Nogami Asako, Takuma Higurashi, Kato Singo, Hosono Kunihiro, Saito Satoru, Nakajima Atsushi：Risk of cardiovascular disease in patients with fatty liver disease as defined from the metabolic dysfunction associated fatty liver disease or nonalcoholic fatty liver disease point of view: a retrospective nationwide claims database study in Japan．Journal of gastroenterology 2021 Nov, 56(11):1022-1032. PMID: 34601620 PMCID: PMC8531127 doi: 10.1007/s00535-021-01828-6. Epub 2021 Oct 3.
  57. Suzuki M, Sekino Y, Hosono K, Kawana K, Nagase H, Kubota K, Nakajima A：Optimal number of needle punctures in endoscopic ultrasound-guided fine-needle biopsy for gastric subepithelial lesions without rapid on-site evaluation．Journal of medical ultrasonics (2001)2021 Oct，48(4):623-629. PMID: 34463865　doi: 10.1007/s10396-021-01129-8. Epub 2021 Aug 31.
  58. Masato Suzuki, Yusuke Sekino, Kunihiro Hosono, Kouji Yamamoto, Kenichi Kawana, Hajime Nagase, Kensuke Kubota, Atsushi Nakajima：Endoscopic Ultrasound versus Magnetic Resonance Cholangiopancreatography for the Diagnosis of Computed Tomography-negative Common Bile Duct Stone: A Prospective Randomized Controlled Trial．Digestive Endoscopy:official journal of the Japan Gastroenterological Endoscopy Society, 2022 Jul;34(5):1052-1059. PMID: 34784076　doi:10.1111/den.14193. Epub 2021 Dec 12.
  59. Kamada Y, Takahashi H, Shimizu M, Kawaguchi T, Sumida Y, Fujii H, Seko Y, Fukunishi S, Tokushige K, Nakajima A, Okanoue T; Japan Study Group of NAFLD (JSG‐NAFLD).：Clinical practice advice on lifestyle modification in the management of nonalcoholic fatty liver disease in Japan: an expert review．Journal of Gastroenterology 2021 Dec, 56(12):1045-1061, PMID: 34718870　 doi: 10.1007/s00535-021-01833-9. Epub 2021 Oct 31　 Online ahead of print.
  60. Katsutoshi Tokushige,Kenichi Ikejima,Masafumi Ono,Yuichiro Eguchi,Yoshihiro Kamada,Yoshito Itoh,Norio Akuta, Masato Yoneda,Motoh Iwasa,Masashi Yoneda,Motoyuki Otsuka,Nobuharu Tamaki,Tomomi Kogiso,Hiroto Miwa,Kazuaki Chayama,Nobuyuki Enomoto,Tooru Shimosegawa,Tetsuo Takehara,Kazuhiko Koike: Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020. Hepatology Research(2021 Oct),51(10):1013-1025, PMID: 34533266 doi: 10.1111/hepr.13688. Epub 2021 Sep 17.
  61. Tsutomu Yoshihara, Mitomu Kioi, Junichi Baba, Haruki Usuda, Takaomi Kessoku, Michihiro Iwaki, Tomohiro Takatsu, Noboru Misawa, Keiichi Ashikari, Tetsuya Matsuura, Akiko Fuyuki, Hidenori Ohkubo, Mitsuharu Matsumoto, Koichiro Wada, Atsushi Nakajima, Takuma Higurashi：A prospective interventional trial on the effect of periodontal treatment on Fusobacterium nucleatum abundance in patients with colorectal tumours．Scientific Reports, 11(1):23719. PMID: 34887459 PMCID: PMC8660914doi: 10.1038/s41598-021-03083-4, 2021 Dec 9.
  62. Atsushi Nakajima,Ayako Shoji,Kinya Kokubo,Ataru Igarashi：A Systematic Review and Network Meta-Analysis on the Efficacy of Medications in the Treatment of Chronic Idiopathic Constipation in Japan. Gastroenterology Research and Practice,Volume 2021:Article ID 5534687 PMID: 34887919 PMCID: PMC8651382 doi: 10.1155/2021/5534687, 2021 Nov 30.
  63. Masashi Izumiya,Shingo Kato,and Yoshitaka Hippo：Recent Advances in Implantation-Based Genetic Modeling of Biliary Carcinogenesis in Mice．Cancers (Basel) 2021 May 11;13(10):2292，PMID: 34064809 PMCID: PMC8151177 doi: 10.3390/cancers13102292.
  64. Kawamura N, Imajo K, Kalutkiewicz KJ, Nagai K, Iwaki M, Kobayashi T, Nogami A, Honda Y, Kessoku T, Ogawa Y, Takuma Higurashi, Hosono K, Takahashi H, Yoneda M, Saito S, Aishima S, Toyoda H, Hayashi H, Sumida Y, Ehman RL, Nakajima A：Influence of liver stiffness heterogeneity on staging fibrosis in patients with nonalcoholic fatty liver disease．Hepatology(Baltimore,Md.) 2022 Jul;76(1):186-195, PMID: 34951726 doi: 10.1002/hep.32302,  Epub 2022 Feb 22.

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